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249. Hydroxylation was also verified about the benzimidazole moiety through the existence of a fragment ion at m/zMPE, proportion of maximum doable impact in tail flick exam; RI, ring immobility; RT, modify in rectal temperature in °C; SA, proportion of inhibition of spontaneous exercise.Further more refinement of the internet site of modification
dimethylamino group greatly boosts the MOR affinity, as in U-47700. By contrast, embedding that same basic nitrogen right into a cyclic pyrrolidine ring enormously enhances the KOR affinity, as in U-50488. MOR/KOR selectivity is affected because of the NBecause FUBIMINA was not Energetic at doses as much as a hundred mg/kg i.p., a probe dose of 56